Abstract
Serglycin is the major cell-associated proteoglycan of hematopoietic cells. Previous work has demonstrated that serglycin may be involved in targeting some proteins to granules of cytotoxic lymphocytes, mast cells and neutrophils. We characterized the expression of serglycin in various hematologic malignancies by immunohistochemistry and ELISA. Serglycin expression was found to distinguish acute myeloid leukemia (AML) from acute lymphoblastic leukemia. In contrast to myeloperoxidase, serglycin was found to be a selective marker for immature myeloid cells, distinguishing AML from Philadelphia chromosome-negative chronic myeloproliferative disorders.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomarkers, Tumor / analysis*
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Blood Cells / chemistry
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Bone Marrow Cells / chemistry
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Cell Differentiation
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Cytoplasmic Granules / chemistry
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Diagnosis, Differential
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Granulocyte Precursor Cells / chemistry*
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Hematologic Neoplasms / diagnosis
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Hematologic Neoplasms / metabolism*
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Humans
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism
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Leukemia, Myeloid, Acute / diagnosis*
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Leukemia, Myeloid, Acute / metabolism
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Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / metabolism
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Lymphoma, Non-Hodgkin / metabolism
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Myeloproliferative Disorders / metabolism
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Neoplasm Proteins / analysis*
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Neoplasm Proteins / blood
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Peroxidase / analysis
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism
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Predictive Value of Tests
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Proteoglycans / analysis*
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Proteoglycans / blood
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Vesicular Transport Proteins / analysis*
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Vesicular Transport Proteins / blood
Substances
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Biomarkers, Tumor
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Neoplasm Proteins
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Proteoglycans
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Vesicular Transport Proteins
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serglycin
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Peroxidase