Abstract
Recent literature has highlighted an important role of inflammation in promoting cancer. However, the immune system can also play a central role in protecting the body against cancer as well as infection, although its role in cancer is not well understood. A study published in the September issue of Nature Medicine adds a new twist to the role of inflammation in cancer. Apetoh et al. describe how activation of innate immunity after conventional radiation or chemotherapy can trigger protective antitumor immunity.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use
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Cell Death
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Dendritic Cells / drug effects
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Dendritic Cells / immunology
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Dendritic Cells / radiation effects
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HMGB1 Protein / metabolism
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Humans
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Immunity, Cellular* / drug effects
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Immunity, Cellular* / radiation effects
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Immunity, Innate* / drug effects
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Immunity, Innate* / radiation effects
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Inflammation / immunology*
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Inflammation / pathology
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Mice
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Myeloid Differentiation Factor 88 / metabolism
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Neoplasms / drug therapy*
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Neoplasms / immunology
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Neoplasms / pathology
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Neoplasms / radiotherapy*
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T-Lymphocytes, Cytotoxic / drug effects
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T-Lymphocytes, Cytotoxic / immunology
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T-Lymphocytes, Cytotoxic / radiation effects
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Toll-Like Receptor 4 / metabolism*
Substances
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Antineoplastic Agents
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HMGB1 Protein
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Myeloid Differentiation Factor 88
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Toll-Like Receptor 4