Abstract
Although the acute clinical effects of ciguatera poisoning, due to ingestion of ciguatoxin, are mediated by activation of transient Na+ channels, the mechanisms underlying ciguatera sensitization remain undefined. Axonal excitability studies were performed by stimulating the median motor and sensory nerves in two patients with ciguatera sensitization. Excitability parameters were all within normal limits, thereby arguing against dysfunction of axonal membrane ion channels in large-diameter fibers in ciguatera sensitization.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / drug effects
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Adult
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Ciguatera Poisoning / pathology*
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Ciguatera Poisoning / physiopathology*
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Confidence Intervals
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Electromyography
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Female
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Humans
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Ion Channels / drug effects
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Ion Channels / physiology*
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Ion Channels / radiation effects
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Middle Aged
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Nerve Fibers / drug effects
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Nerve Fibers / physiology*
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Nerve Fibers / radiation effects
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Peripheral Nerves / drug effects
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Peripheral Nerves / physiopathology*
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Peripheral Nerves / radiation effects