The Emory-Georgia Tech Nanotechnology Center for Personalized and Predictive Oncology is one of the eight national centers funded by the National Cancer Institute (NCI). Its overall goal is to combine nanotechnology and biocomputing with clinical oncology for personalized detection, diagnosis and treatment of human cancer. Within this large-scale and multifaceted center, a key challenge is how to integrate and manage data and resources. Here we have developed an "intelligent" information system for data management, interpretation, and for translation of new results to clinical applications.