Deep subsurface Raman spectroscopy of turbid media by a defocused collection system

Appl Spectrosc. 2007 Oct;61(10):1123-7. doi: 10.1366/000370207782217770.

Abstract

A simple procedure for the recovery of deep subsurface Raman spectra in stratified turbid samples by defocusing a conventional Raman instrument is presented. The method is based on effects present with spatially offset Raman spectroscopy (SORS) and, although not as efficient as the standard SORS approach, it permits a simple way of recovering subsurface Raman spectra from less challenging samples. Demonstration of the effect is performed using a standard SORS device and a commercial Raman instrument on the noninvasive measurement of paracetamol tablets held within a nontransparent white plastic bottle.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colloids / chemistry*
  • Complex Mixtures / chemistry*
  • Equipment Design
  • Equipment Failure Analysis
  • Nephelometry and Turbidimetry / instrumentation*
  • Nephelometry and Turbidimetry / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Spectrum Analysis, Raman / instrumentation*
  • Spectrum Analysis, Raman / methods*

Substances

  • Colloids
  • Complex Mixtures