Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6876-8. doi: 10.1016/j.bmcl.2007.10.013. Epub 2007 Oct 12.

Abstract

A neutrophil-specific peptide, cinnamoyl-F(D)LF(D)LFK (cFLFLFK), was conjugated consecutively with a polyethylene glycol moiety (3.4K) and 2,2',2'',2'''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) to form cFLFLFK-PEG-DOTA. After (64)Cu labeling, Positron Emission Tomography (PET) imaging was successfully able to detect mouse lung inflammation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromatography, High Pressure Liquid
  • Mice
  • Molecular Structure
  • Neutrophils* / drug effects
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Peptides / pharmacology*
  • Positron-Emission Tomography / methods*

Substances

  • Peptides