Abstract
We investigated a patient with type 1 diabetes mellitus undergoing pancreatic islets transplantation. In this patient, we evaluated the clinical usefulness of serial measurement of serum S100A8/A9 complex levels for detecting acute inflammatory responses associated with rejection of transplanted pancreatic islets. The serum S100A8/A9 complex was a more sensitive marker for acute inflammation associated with islet transplant rejection than the serum C-reactive protein. Thus, the serial measurement of the serum S100A8/A9 complex concentration is useful for monitoring the patients with pancreatic islet transplantation.
Publication types
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Case Reports
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Evaluation Study
MeSH terms
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Alanine Transaminase / blood
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Aspartate Aminotransferases / blood
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Biomarkers / blood
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Blood Glucose / analysis
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C-Reactive Protein / analysis
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Calgranulin A / blood*
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Calgranulin B / blood*
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Diabetes Mellitus, Type 1 / blood
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Diabetes Mellitus, Type 1 / complications
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Diabetes Mellitus, Type 1 / diagnosis
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Diabetes Mellitus, Type 1 / therapy*
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Humans
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Inflammation / diagnosis*
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Inflammation / etiology*
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Islets of Langerhans Transplantation / adverse effects*
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Male
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Middle Aged
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Postoperative Period
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Prognosis
Substances
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Biomarkers
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Blood Glucose
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Calgranulin A
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Calgranulin B
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C-Reactive Protein
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Aspartate Aminotransferases
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Alanine Transaminase