Microwave assisted synthesis of N-arylheterocyclic substituted-4-aminoquinazoline derivatives

Gang Liu; Song Yang; Baoan Song; Wei Xue; Deyu Hu; Linhong Jin; Ping Lu

doi:10.3390/11040272

Microwave assisted synthesis of N-arylheterocyclic substituted-4-aminoquinazoline derivatives

Molecules. 2006 Apr 10;11(4):272-8. doi: 10.3390/11040272.

Authors

Gang Liu¹, Song Yang, Baoan Song, Wei Xue, Deyu Hu, Linhong Jin, Ping Lu

Affiliation

¹ Center for Research and Development of Fine Chemicals, Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guiyang, 550025, P. R. China.

Abstract

A simple, efficient, and general method has been developed for the synthesis of various N-aryl heterocylic substituted-4-aminoquinazoline compounds from 4-chloro- quinazoline and aryl heterocyclic amines under microwave irradiation using 2-propanol as solvent. The advantages of the use of microwave irradiation in relation to the classical method were demonstrated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Heterocyclic Compounds / chemistry*
Magnetic Resonance Spectroscopy
Microwaves*
Quinazolines / chemical synthesis*
Quinazolines / chemistry

Substances

Heterocyclic Compounds
Quinazolines