A polyacetylene compound from herbal medicine regulates genes associated with thrombosis in endothelial cells

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6879-82. doi: 10.1016/j.bmcl.2007.10.015. Epub 2007 Oct 12.

Abstract

From Toki-shakuyaku-san, an herbal formulation for 'cleansing stagnated blood,' a key gene regulatory compound was purified and identified through a screening based on DNA microarray and real-time PCR.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cells, Cultured
  • Endothelial Cells / drug effects*
  • Endothelial Cells / metabolism*
  • Gene Expression Regulation / drug effects*
  • Herbal Medicine*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Polyynes / chemistry*
  • Polyynes / isolation & purification
  • Polyynes / pharmacology*
  • Thrombosis / metabolism*

Substances

  • Plant Extracts
  • Polyynes