Disparity between Yersinia pestis and Yersinia enterocolitica O:8 in YopJ/YopP-dependent functions

Adv Exp Med Biol. 2007:603:312-20. doi: 10.1007/978-0-387-72124-8_28.

Abstract

YopP in Y. enterocolitica and YopJ in Y. pseudotuberculosis, have been shown to exert a variety of adverse effects on cell signaling leading to suppression of cytokine expression and induction of programmed cell death. A comparative in vitro study with Y. pestis and Y. enterocolitica O:8 virulent strains shows some critical disparity in YopJ/YopP-related effects on immune cells. Involvement of yopJ in virulence was evaluated in mouse model of bubonic plague.

Publication types

  • Comparative Study

MeSH terms

  • Apoptosis
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology*
  • Genes, Bacterial
  • Host-Pathogen Interactions
  • Humans
  • MAP Kinase Signaling System
  • NF-kappa B / metabolism
  • Signal Transduction
  • Species Specificity
  • Tumor Necrosis Factor-alpha / biosynthesis
  • Yersinia enterocolitica / genetics
  • Yersinia enterocolitica / pathogenicity
  • Yersinia enterocolitica / physiology*
  • Yersinia pestis / genetics
  • Yersinia pestis / pathogenicity
  • Yersinia pestis / physiology*

Substances

  • Bacterial Proteins
  • NF-kappa B
  • Tumor Necrosis Factor-alpha
  • YopP protein, Yersinia