Abstract
We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Antigens, Bacterial / immunology
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Bacterial Proteins / immunology
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Child
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Child, Preschool
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Female
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Humans
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Interferon-gamma / blood*
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Interferon-gamma / immunology
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Male
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Middle Aged
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Mycobacterium tuberculosis / immunology*
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Mycobacterium tuberculosis / isolation & purification
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Peptides / immunology
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Prospective Studies
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Reagent Kits, Diagnostic*
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Tuberculin Test / methods
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Tuberculosis / blood
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Tuberculosis / diagnosis*
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Tuberculosis / immunology
Substances
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Antigens, Bacterial
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Bacterial Proteins
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CFP-10 protein, Mycobacterium tuberculosis
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ESAT-6 protein, Mycobacterium tuberculosis
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Peptides
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Reagent Kits, Diagnostic
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Interferon-gamma