Abstract
This meta-analysis assessed aggression and/or hostility-related events in children and adolescents treated with fluoxetine (n = 376) compared with placebo (n = 255). Aggression and/or hostility-related events were identified in 2.1% of fluoxetine versus 3.1% of placebo-treated patients (p = 0.588). This analysis fails to support an association between fluoxetine treatment and increased risk of aggression and/or hostility-related events in children and adolescents compared with placebo.
Publication types
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Meta-Analysis
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adolescent
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Aggression / drug effects*
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Aggression / psychology
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Antidepressive Agents, Second-Generation / adverse effects*
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Antidepressive Agents, Second-Generation / therapeutic use
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Child
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Depressive Disorder, Major / complications
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Depressive Disorder, Major / drug therapy
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Female
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Fluoxetine / adverse effects*
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Fluoxetine / therapeutic use
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Hostility*
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Humans
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Male
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Obsessive-Compulsive Disorder / complications
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Obsessive-Compulsive Disorder / drug therapy
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Psychiatric Status Rating Scales
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Randomized Controlled Trials as Topic
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Risk
Substances
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Antidepressive Agents, Second-Generation
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Fluoxetine