Abstract
Darunavir is a nonpeptidic protease inhibitor recently approved for the treatment of antiretroviral therapy-experienced patients. It has potent in vitro activity against viral isolates that are resistant to currently licensed protease inhibitors. In randomized clinical trials with optimized background regimens, it has shown virologic and immunologic responses superior to comparator-based regimens.
2007 Prous Science
MeSH terms
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Clinical Trials as Topic
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Darunavir
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Drug Interactions
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Drug Resistance, Viral
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Drug Therapy, Combination
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HIV Infections / drug therapy*
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HIV Protease Inhibitors / adverse effects
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HIV Protease Inhibitors / pharmacology
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HIV Protease Inhibitors / therapeutic use*
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Humans
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Sulfonamides / adverse effects
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Sulfonamides / pharmacology
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Sulfonamides / therapeutic use*
Substances
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HIV Protease Inhibitors
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Sulfonamides
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Darunavir