Coronary revascularization using percutaneous coronary intervention (PCI) has rapidly developed in the past 2 decades and its technical and pharmaceutical improvements may avoid bypass surgery in many situations. The use of drug-eluting stents (DES) challenges the classic indications for bypass surgery and shifts them toward PCI, with the need for a critical appreciation of procedure- and patient-related risks. Furthermore, invasive measures such as intravascular ultrasound or pressure wire allow lesion-specific and immediate therapeutic decisions. This overview summarizes the actual potential of coronary intervention. To be aware of potentials and limitations may help the non-interventionalist to advise his patient and to choose the appropriate treatment.