AROuSing SIRT1: identification of a novel endogenous SIRT1 activator

Mol Cell. 2007 Nov 9;28(3):354-6. doi: 10.1016/j.molcel.2007.10.013.

Abstract

SIRT1 is a protein deacetylase that regulates cellular responses to a variety of stresses. In a recent issue of Molecular Cell, Kim et al. (2007) report the identification of a cellular protein, AROS, that activates the SIRT1-mediated deacetylation of p53.

Publication types

  • Review
  • Comment

MeSH terms

  • Acetylation
  • Enzyme Activation
  • Enzyme Activators / chemistry
  • Enzyme Activators / pharmacology
  • Humans
  • Nuclear Proteins / metabolism
  • Nuclear Proteins / physiology*
  • Resveratrol
  • Sirtuin 1
  • Sirtuins / antagonists & inhibitors
  • Sirtuins / genetics
  • Sirtuins / metabolism*
  • Stilbenes / chemistry
  • Stilbenes / pharmacology
  • Transcription Factors / metabolism
  • Transcription Factors / physiology*
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Enzyme Activators
  • Nuclear Proteins
  • RPS19BP1 protein, human
  • Stilbenes
  • Transcription Factors
  • Tumor Suppressor Protein p53
  • SIRT1 protein, human
  • Sirtuin 1
  • Sirtuins
  • Resveratrol