Prediction of glucose excursions under uncertain parameters and food intake in intensive insulin therapy for type 1 diabetes mellitus

Annu Int Conf IEEE Eng Med Biol Soc. 2007:2007:1770-3. doi: 10.1109/IEMBS.2007.4352654.

Abstract

Considering the difficulty in the insulin dosage selection and the problem of hyper-and hypoglycaemia episodes in type 1 diabetes, dosage-aid systems appear as tremendously helpful for these patients. A model-based approach to this problem must unavoidably consider uncertainty sources such as the large intra-patient variability and food intake. This work addresses the prediction of glycaemia for a given insulin therapy face to parametric and input uncertainty, by means of modal interval analysis. As result, a band containing all possible glucose excursions suffered by the patient for the given uncertainty is obtained. From it, a safer prediction of possible hyper-and hypoglycaemia episodes can be calculated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Blood Glucose / analysis*
  • Carbohydrates
  • Diabetes Mellitus, Type 1 / therapy*
  • Diet
  • Eating*
  • Glucose / analysis*
  • Glucose / metabolism
  • Humans
  • Hypoglycemia / diagnosis
  • Insulin / pharmacokinetics
  • Insulin / therapeutic use*
  • Models, Statistical
  • Models, Theoretical
  • Reproducibility of Results
  • Time Factors

Substances

  • Blood Glucose
  • Carbohydrates
  • Insulin
  • Glucose