MDRView: a visualization of the polymorphisms of MDR1(ABCB1) GENE in breast cancer

Edlira Xhemo; Anne Fajac; Jean-Yves Boire; Pierre Levy

doi:10.1109/IEMBS.2007.4353362

MDRView: a visualization of the polymorphisms of MDR1(ABCB1) GENE in breast cancer

Annu Int Conf IEEE Eng Med Biol Soc. 2007:2007:4592-4. doi: 10.1109/IEMBS.2007.4353362.

Authors

Edlira Xhemo¹, Anne Fajac, Jean-Yves Boire, Pierre Levy

Affiliation

¹ Public Health Department, Tenon Hospital, 75020 Paris, France. [email protected]

PMID: 18003028
DOI: 10.1109/IEMBS.2007.4353362

Abstract

This paper presents the Generalized CaseView method applied to the study of polymorphisms of MDR1 (Multi Drug Resistant), a gene coding for a trans-membrane transporting protein. The data base contains Single nucleotide polymorphisms, their positions in cDNA, and the Area Under the Curve of drugs concentrations. The generalized CaseView method permits a compact visualization of these data. The main result is that pharmacokinetics of some anticancer drugs depends on the genotype.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics*
ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
Antineoplastic Combined Chemotherapy Protocols / pharmacokinetics*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Area Under Curve
Breast Neoplasms / drug therapy
Breast Neoplasms / genetics*
Docetaxel
Doxorubicin / pharmacokinetics
Doxorubicin / therapeutic use
Female
Humans
Polymorphism, Single Nucleotide*
Software*
Taxoids / pharmacokinetics
Taxoids / therapeutic use

Substances

ABCB1 protein, human
ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1
Taxoids
Docetaxel
Doxorubicin