Abstract
An increasing number of new hepatitis C virus NS3-protease inhibitors are being evaluated for the treatment of chronic hepatitis C. Treatment-induced selection of mutants conferring resistance to protease inhibitors has been shown both in vivo and in vitro. A specific mutation, A156T has been shown to confer high-level resistance to several such agents (BILN2061, VX-950, SCH446211 (SCH6) and SCH503034). Here we report the presence of the A156T mutation in close to 1% of NS3 sequences within the liver quasispecies of a chronic hepatitis C patient never treated with anti-NS3-protease inhibitors.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amino Acid Sequence
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Base Sequence
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Carbamates / pharmacology
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DNA, Viral / genetics
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Drug Resistance, Viral / genetics
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Genes, Viral
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Hepacivirus / drug effects
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Hepacivirus / enzymology*
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Hepacivirus / genetics*
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Hepatitis C, Chronic / virology*
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Humans
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Liver / virology
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Macrocyclic Compounds / pharmacology
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Male
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Molecular Sequence Data
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Oligopeptides / pharmacology
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Point Mutation*
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Proline / analogs & derivatives
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Proline / pharmacology
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Quinolines / pharmacology
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Sequence Homology, Amino Acid
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Sequence Homology, Nucleic Acid
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Serine Endopeptidases / genetics*
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Serine Proteinase Inhibitors / pharmacology
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Thiazoles / pharmacology
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Viral Nonstructural Proteins / genetics*
Substances
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BILN 2061
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Carbamates
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DNA, Viral
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Macrocyclic Compounds
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NS3 protein, hepatitis C virus
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Oligopeptides
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Quinolines
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SCH6
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Serine Proteinase Inhibitors
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Thiazoles
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Viral Nonstructural Proteins
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telaprevir
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N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide
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Proline
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Serine Endopeptidases
Associated data
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GENBANK/EF613694
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GENBANK/EF613695
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GENBANK/EF613696
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GENBANK/EF613697
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GENBANK/EF613698
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GENBANK/EF613699
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GENBANK/EF613700
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GENBANK/EF613701
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GENBANK/EF613702
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GENBANK/EF613703
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GENBANK/EF613704
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GENBANK/EF613705
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GENBANK/EF613706
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GENBANK/EF613707
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GENBANK/EF613708
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GENBANK/EF613709
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GENBANK/EF613710
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GENBANK/EF613711
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GENBANK/EF613712
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GENBANK/EF613713
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GENBANK/EF613714
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GENBANK/EF613715
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GENBANK/EF613716
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GENBANK/EF613717
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GENBANK/EF613718
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GENBANK/EF613719
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GENBANK/EF613720
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GENBANK/EF613721
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GENBANK/EF613722
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GENBANK/EF613723
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GENBANK/EF613724
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GENBANK/EF613725