Abstract
A family of terpyridine metallo-organic complexes has been designed and its recognition properties of G-quadruplex-DNA investigated. The series combines easy synthetic access and good affinity-selectivity ratio for quadruplex-DNA. Our study also highlights that the geometry of the metal center strongly governs the ability of the compounds to discriminate quadruplex from duplex-DNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding, Competitive
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Crystallography, X-Ray
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Fluorescence Resonance Energy Transfer
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G-Quadruplexes*
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Ligands
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Metals, Heavy / chemistry*
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Models, Molecular
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Molecular Structure
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Nucleic Acid Conformation
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry*
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Pyridines / chemistry*
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Structure-Activity Relationship
Substances
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Ligands
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Metals, Heavy
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Organometallic Compounds
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Pyridines