Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells

Len Neckers; Adam Kern; Shinji Tsutsumi

doi:10.1016/j.chembiol.2007.11.002

Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells

Chem Biol. 2007 Nov;14(11):1204-6. doi: 10.1016/j.chembiol.2007.11.002.

Authors

Len Neckers¹, Adam Kern, Shinji Tsutsumi

Affiliation

¹ Urologic Oncology Branch, Center for Cancer Research, NCI, 9000 Rockville Pike, Bldg. 10/CRC, Room 1-5940, Bethesda, MD 20892, USA. [email protected]

PMID: 18022558
DOI: 10.1016/j.chembiol.2007.11.002

Abstract

Hsp90 is a cytosolic molecular chaperone whose paralog in mitochondria, TRAP1, protects cells from oxidative stress. The recent study in Cell by Kang et al. now identifies the molecular components of the proapoptotic network regulated by TRAP1, that includes Hsp90. Targeting Hsp90/TRAP1 inhibitors to mitochondria induces rapid tumor cell-specific apoptosis.

MeSH terms

Apoptosis
HSP90 Heat-Shock Proteins / antagonists & inhibitors*
Homeostasis*
Humans
Mitochondria / drug effects*
Mitochondria / physiology
Neoplasms / pathology
Neoplasms / physiopathology*

Substances

HSP90 Heat-Shock Proteins