Abstract
LuxS catalyzes the synthesis of the quorum-sensing signaling molecule autoinducer 2. We show that in Salmonella enterica serovar Typhimurium, deletion of the luxS gene polarizes flagellar phase variation toward the more immunogenic phase 1 flagellin. This phenotype is complementable by luxS in trans but is independent of quorum-sensing signals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Carbon-Sulfur Lyases / genetics
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Carbon-Sulfur Lyases / metabolism*
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Flagella / chemistry*
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Flagella / immunology
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Flagellin / immunology
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Flagellin / metabolism*
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Gene Deletion
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Genetic Complementation Test
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Quorum Sensing
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Salmonella typhimurium / metabolism*
Substances
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Bacterial Proteins
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Flagellin
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Carbon-Sulfur Lyases
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LuxS protein, Bacteria