Abstract
The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles*
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Animals
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Antimalarials / pharmacology*
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Antimalarials / therapeutic use
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Dihydropteroate Synthase / genetics
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Drug Combinations
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Drug Resistance / genetics*
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Health Policy*
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Humans
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Malaria, Falciparum / drug therapy*
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Malaria, Falciparum / epidemiology*
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Mutation
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Peru
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Plasmodium falciparum / drug effects
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Plasmodium falciparum / enzymology
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Plasmodium falciparum / genetics
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Pyrimethamine / pharmacology*
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Pyrimethamine / therapeutic use
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Sulfadoxine / pharmacology*
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Sulfadoxine / therapeutic use
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Tetrahydrofolate Dehydrogenase / genetics
Substances
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Antimalarials
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Drug Combinations
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fanasil, pyrimethamine drug combination
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Sulfadoxine
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Tetrahydrofolate Dehydrogenase
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Dihydropteroate Synthase
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Pyrimethamine