Synthesis and conformational studies of pseudopeptides containing an unsymmetrical triazine scaffold

J Pept Sci. 2008 May;14(5):596-609. doi: 10.1002/psc.944.

Abstract

Solid-phase synthesis and conformational studies of two pseudopeptides constituted by a triazine scaffold bound to two peptidic arms are described. In this paper, a new scaffold based on unsymmetrical triamino 1,3,5-triazine bearing two alkyl chains has been designed, assisted by molecular modelling, as a mimic of the backbone of the i + 1 and i + 2 residues of a beta-turn. The results confirm the ability of the triazine scaffold to induce extended conformations of the peptidic strands and point out that this scaffold is a good candidate as a template to induce anti-parallel beta-sheet structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Biomimetic Materials / chemical synthesis
  • Biomimetic Materials / chemistry
  • Hydrogen Bonding
  • Indicators and Reagents
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / chemistry*
  • Protein Conformation
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Triazines / chemical synthesis
  • Triazines / chemistry

Substances

  • Indicators and Reagents
  • Oligopeptides
  • Triazines