Synthesis of DNA duplexes containing complexes of 5-modified pyrimidine bases and metal ions

Nucleic Acids Symp Ser (Oxf). 2007:(51):181-2. doi: 10.1093/nass/nrm091.

Abstract

DNA duplexes carrying metal ions at the 5-position of uracil residues were synthesized by mixing oligodeoxyribonucleotides (ODNs) containing 5-formyl uracils, metal ions, and amines. A metal ion binding site may form from the 5-formyl residue and amines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Pairing
  • DNA / chemical synthesis
  • DNA / chemistry*
  • Ions / chemistry
  • Metals / chemistry*
  • Nucleic Acid Denaturation
  • Oligodeoxyribonucleotides / chemical synthesis
  • Oligodeoxyribonucleotides / chemistry
  • Uracil / analogs & derivatives*
  • Uracil / chemistry

Substances

  • Ions
  • Metals
  • Oligodeoxyribonucleotides
  • 5-formyluracil
  • Uracil
  • DNA