Successful treatment of multi-resistant Pseudomonas aeruginosa osteomyelitis after allogeneic bone marrow transplantation with a combination of colistin and tigecycline

J Med Microbiol. 2007 Dec;56(Pt 12):1692-1695. doi: 10.1099/jmm.0.47286-0.

Abstract

A case of osteomyelitis caused by multidrug-resistant Pseudomonas aeruginosa is reported in a patient who underwent allogeneic bone marrow transplantation for acute lymphoblastic leukaemia. The patient was successfully treated by prolonged administration of a full dose of colistin and tigecycline, and surgical curettage with the positioning of resorbable calcium sulfate pellets loaded with colistin.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Bone Marrow Transplantation / adverse effects*
  • Colistin / therapeutic use*
  • Drug Resistance, Multiple, Bacterial
  • Drug Therapy, Combination
  • Female
  • Humans
  • Minocycline / analogs & derivatives*
  • Minocycline / therapeutic use
  • Osteomyelitis / complications
  • Osteomyelitis / drug therapy*
  • Osteomyelitis / microbiology
  • Pseudomonas Infections / complications
  • Pseudomonas Infections / drug therapy*
  • Pseudomonas Infections / microbiology
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / isolation & purification
  • Tigecycline
  • Transplantation, Homologous

Substances

  • Anti-Bacterial Agents
  • Tigecycline
  • Minocycline
  • Colistin