Confirmation of a novel recurrent association: BCR-ABL t(9;22) and t(19;21)

Stéphanie Struski; Catherine Hélias; Carine Gervais; Vincent Leymarie; Bruno Audhuy; Philippe Moskovtchenko; Patrick Lutz; Marie-Pierre Gaub; Michel Lessard

doi:10.1016/j.cancergencyto.2007.08.004

Confirmation of a novel recurrent association: BCR-ABL t(9;22) and t(19;21)

Cancer Genet Cytogenet. 2007 Dec;179(2):127-31. doi: 10.1016/j.cancergencyto.2007.08.004.

Authors

Stéphanie Struski¹, Catherine Hélias, Carine Gervais, Vincent Leymarie, Bruno Audhuy, Philippe Moskovtchenko, Patrick Lutz, Marie-Pierre Gaub, Michel Lessard

Affiliation

¹ Institute of Hematology, Faculty of Medicine, 4 rue Kirschleger, 67000 Strasbourg, France. [email protected]

PMID: 18036399
DOI: 10.1016/j.cancergencyto.2007.08.004

Abstract

Association of a t(9;22)(q34;q11), BCR/ABL-positive, with a dic(19;21)(p13;p13) has been described in acute lymphoblastic leukemia in relapse, raising the question of whether this association is recurrent. Described here are two cases, one of myeloproliferative disease and one of acute lymphoblastic leukemia, both presenting a masked t(9;22) and t(19;21). Chromosomal rearrangements were ascertained by fluorescence in situ hybridization (FISH) using locus-specific probes, multicolor FISH, and bacterial artificial chromosome array. These additional observations suggest a nonrandom association.

Publication types

Case Reports

MeSH terms

Adolescent
Aged
Burkitt Lymphoma / genetics*
Chromosomes, Human, Pair 19*
Chromosomes, Human, Pair 21*
Chromosomes, Human, Pair 22*
Chromosomes, Human, Pair 9*
Female
Fusion Proteins, bcr-abl / metabolism*
Humans
In Situ Hybridization, Fluorescence
Male
Myeloproliferative Disorders / genetics*
Translocation, Genetic*

Substances

Fusion Proteins, bcr-abl