Abstract
Objective:
To evaluate in vitro the effect of coenzyme Q10 (CoQ(10)) on ischemia-induced hair cell death.
Study design:
Organotypic cochlear cultures of newborn rats were subjected to ischemia with and without CoQ(10).
Results:
Addition of CoQ(10) has not prevented HC loss.
Conclusion:
CoQ(10) seems to protect against only certain modes of cell death.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Newborn
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Carbon Dioxide / pharmacology
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Cell Death / drug effects
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Cell Survival / drug effects
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Coenzymes / pharmacology
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Electron Transport Chain Complex Proteins / pharmacology*
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Hair Cells, Auditory / drug effects*
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Ischemia / physiopathology*
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Nitrogen / pharmacology
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Organ Culture Techniques
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Perilymph / physiology
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Protective Agents / pharmacology*
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Rats
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Rats, Wistar
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Ubiquinone / analogs & derivatives*
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Ubiquinone / pharmacology
Substances
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Coenzymes
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Electron Transport Chain Complex Proteins
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Protective Agents
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Ubiquinone
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Carbon Dioxide
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coenzyme Q10
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Nitrogen