Background and purpose: We evaluated the association between recombinant tissue-type plasminogen activator recanalization and change in hemostatic markers.
Methods: We studied 40 patients. Recanalization was measured with transcranial Doppler. We evaluated the change in markers of coagulation (fibrinogen) and fibrinolysis (thrombin activatable fibrinolysis inhibitor and alpha(2)-antiplasmin) in patients with ischemic stroke treated with recombinant tissue-type plasminogen activator. Samples were obtained before and 90 minutes after recombinant tissue-type plasminogen activator infusion.
Results: The analyses (2-way analysis of variance) showed that the change in the value of each marker did not depend on the vascular patency status.
Conclusions: From a practical point of view, the measurement of these hemostatic markers is probably not useful for predicting recanalization.