Abstract
A new dihydropyranone, ( R)-6-[( S)-2-hydroxy-4-(4-hydroxyphenyl)butyl]-5,6-dihydropyran-2-one ( 1), was isolated from Tapinanthus dodoneifolius. The structure was determined from spectroscopic and X-ray crystallographic analysis. Compound 1 (named dodoneine) showed a relaxing effect on preconstricted rat aortic rings (IC 50 of 81.4 +/- 0.9 microM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Africa, Western
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Animals
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Aorta / drug effects*
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Crystallography, X-Ray
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Loranthaceae / chemistry*
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Molecular Conformation
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Molecular Structure
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Plants, Medicinal / chemistry*
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Pyrones / chemistry
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Pyrones / isolation & purification*
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Pyrones / pharmacology
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Rats
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Stereoisomerism
Substances
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( R)-6-(( S)-2-hydroxy-4-(4-hydroxyphenyl)butyl)-5,6-dihydropyran-2-one
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Pyrones