Abstract
Objectives:
The role of SLC19A1 -43T>C, MTHFR 677C>T and MS 2756A>G polymorphisms on red cell and plasma folate levels.
Design and methods:
Genotype analysis of the three polymorphisms. Red cell and plasma folate measurements in 64 patients with coronary artery disease.
Results:
The non-wild type allele of SLC19A1 polymorphism -43T>C was associated with low red cell folate levels and the non-wild type allele of MTHFR polymorphism 677C>T with low plasma folate levels.
Conclusion:
SLC19A1 and MTHFR genes are differently associated with red cell and plasma folate levels.
MeSH terms
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5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / blood
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5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / genetics
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Biomarkers / blood
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Coronary Artery Disease / blood
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Coronary Artery Disease / genetics
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Erythrocytes / chemistry
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Erythrocytes / metabolism*
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Female
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Folic Acid / blood*
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Folic Acid / genetics
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Folic Acid Deficiency / blood
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Folic Acid Deficiency / genetics
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Genetic Predisposition to Disease
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Humans
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Male
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Membrane Transport Proteins / blood
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Membrane Transport Proteins / genetics*
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Methylenetetrahydrofolate Reductase (NADPH2) / blood
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Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
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Middle Aged
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Polymorphism, Single Nucleotide / genetics*
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Reduced Folate Carrier Protein
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Serum / chemistry
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Serum / metabolism*
Substances
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Biomarkers
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Membrane Transport Proteins
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Reduced Folate Carrier Protein
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SLC19A1 protein, human
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Folic Acid
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Methylenetetrahydrofolate Reductase (NADPH2)
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5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase