Furano- and pyrrolo [2,3-d] pyrimidine nucleosides and their 5'-O-triphospates: synthesis and enzymatic activity

L A Alexandrova; M A Ivanov; L S Victorova; M K Kukhanova

doi:10.1080/15257770701516250

Furano- and pyrrolo [2,3-d] pyrimidine nucleosides and their 5'-O-triphospates: synthesis and enzymatic activity

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1083-6. doi: 10.1080/15257770701516250.

Authors

L A Alexandrova¹, M A Ivanov, L S Victorova, M K Kukhanova

Affiliation

¹ Engelhardt Institute of Molecular Biology RAS, Moscow, Russia. [email protected]

PMID: 18058541
DOI: 10.1080/15257770701516250

Abstract

A series of bicyclic [2,3-d]furano- and pyrrolopyrimidine ribonucleosides were synthesized and converted chemically into corresponding 5'-O-triphosphates. Substrate properties of the triphosphates toward some RNA and DNA polymerases are reported.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / chemical synthesis
Antiviral Agents / chemistry
Antiviral Agents / metabolism
Antiviral Agents / pharmacology
Bridged Bicyclo Compounds / chemical synthesis
Bridged Bicyclo Compounds / chemistry
Bridged Bicyclo Compounds / metabolism
Cattle
DNA-Directed DNA Polymerase / metabolism
DNA-Directed RNA Polymerases / metabolism
Drug Design
HIV Reverse Transcriptase / antagonists & inhibitors
Hepacivirus / drug effects
Hepacivirus / enzymology
Molecular Structure
Pyrimidine Nucleosides / chemical synthesis*
Pyrimidine Nucleosides / chemistry
Pyrimidine Nucleosides / metabolism*
Pyrimidine Nucleosides / pharmacology
Pyrimidine Nucleotides / chemical synthesis*
Pyrimidine Nucleotides / chemistry
Pyrimidine Nucleotides / metabolism*
Pyrimidine Nucleotides / pharmacology
Substrate Specificity

Substances

Antiviral Agents
Bridged Bicyclo Compounds
Pyrimidine Nucleosides
Pyrimidine Nucleotides
HIV Reverse Transcriptase
DNA-Directed RNA Polymerases
DNA-Directed DNA Polymerase