The nonspecific colon ulcer is a not a well-known disorder. A case of ulcer of the colic hepatic flexure is described. It was a case of pseudotumor and the pathological examination confirmed the diagnosis. The precise diagnosis of colon ulcer is useful for conservative treatment with coloscopic surveillance and to prevent a hemorrhagic complication or peritonitis after perforation. Contrary to diverticulitis, this pathology is most dominant on the right colon and particularly on the cecum. This explains the frequency of pseudoappendicular syndromes.