Efficient synthesis of benzamide riboside, a potential anticancer agent

Laurent F Bonnac; Guang-Yao Gao; Liqiang Chen; Steven E Patterson; Hiremagalur N Jayaram; Krzysztof W Pankiewicz

doi:10.1080/15257770701528222

Efficient synthesis of benzamide riboside, a potential anticancer agent

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1249-53. doi: 10.1080/15257770701528222.

Authors

Laurent F Bonnac¹, Guang-Yao Gao, Liqiang Chen, Steven E Patterson, Hiremagalur N Jayaram, Krzysztof W Pankiewicz

Affiliation

¹ Center for Drug Design, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN 55455, USA.

PMID: 18066762
DOI: 10.1080/15257770701528222

Abstract

An efficient five step synthesis of benzamide riboside (BR) amenable for a large scale synthesis has been developed. It allows for extensive pre-clinical studies of BR as a potential anticancer agent.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology
Humans
IMP Dehydrogenase / antagonists & inhibitors*
Nicotinamide-Nucleotide Adenylyltransferase / chemistry
Nucleosides / biosynthesis
Nucleosides / chemical synthesis*
Nucleosides / pharmacology

Substances

Antineoplastic Agents
Enzyme Inhibitors
Nucleosides
3-(1-deoxyribofuranosyl)benzamide
IMP Dehydrogenase
Nicotinamide-Nucleotide Adenylyltransferase