N2'-functionalized 2'-amino-alpha-L-LNA adenine derivatives--efficient targeting of single stranded DNA

Nicolai K Andersen; Jesper Wengel; Patrick J Hrdlicka

doi:10.1080/15257770701539153

N2'-functionalized 2'-amino-alpha-L-LNA adenine derivatives--efficient targeting of single stranded DNA

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1415-7. doi: 10.1080/15257770701539153.

Authors

Nicolai K Andersen¹, Jesper Wengel, Patrick J Hrdlicka

Affiliation

¹ Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Odense M, Denmark.

PMID: 18066795
DOI: 10.1080/15257770701539153

Abstract

The synthesis of two pyrene-functionalized 2'-amino-alpha-L-LNA adenine building blocks is outlined and initial results from thermal denaturation studies are presented.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenine / chemistry*
DNA, Single-Stranded / chemistry*
Nucleic Acid Denaturation
Oligodeoxyribonucleotides / chemistry*
Oligonucleotides / chemistry*
Pyridines / chemistry*
RNA / chemistry
Thymidine Monophosphate / analogs & derivatives*
Thymidine Monophosphate / chemistry

Substances

2'-N-(pyren-1-yl)acetyl-2'-amino-alpha-L-LNA
DNA, Single-Stranded
Oligodeoxyribonucleotides
Oligonucleotides
Pyridines
Thymidine Monophosphate
RNA
Adenine