Abstract
Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / pharmacology*
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Antifungal Agents / therapeutic use
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Calcineurin Inhibitors*
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Cryptococcosis / drug therapy*
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Cryptococcosis / microbiology
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Cryptococcus neoformans / drug effects*
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Drug Synergism
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Humans
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Immunosuppressive Agents / pharmacology*
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Immunosuppressive Agents / therapeutic use
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Microbial Sensitivity Tests
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Organ Transplantation / adverse effects*
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Tacrolimus / pharmacology*
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Tacrolimus / therapeutic use
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Treatment Outcome
Substances
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Antifungal Agents
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Calcineurin Inhibitors
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Immunosuppressive Agents
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Tacrolimus