Anthraquinones with quinone reductase-inducing activity and benzophenones from Morinda citrifolia (noni) roots

J Nat Prod. 2007 Dec;70(12):2049-52. doi: 10.1021/np070501z. Epub 2007 Dec 13.

Abstract

Two new benzophenones, morintrifolins A ( 1) and B ( 2), together with 14 known anthraquinones and four other known compounds, were isolated from a chloroform-soluble extract of Morinda citrifolia roots. Of the isolated compounds, four known anthraquinones, namely, 1,2-dihydroxyanthraquinone ( 3), 1,3-dihydroxy-2-methylanthraquinone ( 4), 2-hydroxy-3-(hydroxymethyl)anthraquinone ( 5), and 1,3,6-trihydroxy-2-methylanthraquinone ( 6), exhibited quinone reductase (QR)- inducing activity in Hepa lclc7 cells, with concentrations required to double QR activity of 12.0, 8.1, 0.94, and 0.56 microM, respectively.

MeSH terms

  • Animals
  • Anthraquinones / chemistry
  • Anthraquinones / isolation & purification*
  • Anthraquinones / pharmacology*
  • Benzophenones / chemistry
  • Benzophenones / isolation & purification*
  • Benzophenones / pharmacology*
  • Mice
  • Molecular Structure
  • Morinda / chemistry*
  • NAD(P)H Dehydrogenase (Quinone) / antagonists & inhibitors*
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Utah

Substances

  • Anthraquinones
  • Benzophenones
  • morintrifolin A
  • morintrifolin B
  • NAD(P)H Dehydrogenase (Quinone)