Abstract
An overview is given on current efforts in drug development based on plant-derived natural products. Emphasis is on projects which have advanced to clinical development. Therapeutic areas covered include cancer, viral infections including HIV, malaria, inflammatory diseases, nociception and vaccine adjuvants, metabolic disorders, and neurodegenerative diseases. Aspects which are specific to plant-based drug discovery and development are also addressed, such as supply issues in the commercial development, and the Convention on Biological Diversity.
MeSH terms
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Adjuvants, Immunologic / isolation & purification
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Adjuvants, Immunologic / therapeutic use
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Alzheimer Disease / drug therapy
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Analgesics / isolation & purification
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Analgesics / therapeutic use
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Animals
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / therapeutic use
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Antimalarials / isolation & purification
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Antimalarials / therapeutic use
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / therapeutic use
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Antiviral Agents / isolation & purification
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Antiviral Agents / therapeutic use
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Cardiovascular Agents / isolation & purification
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Cardiovascular Agents / therapeutic use
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Drug Design*
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Humans
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / therapeutic use
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Molecular Structure
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Neuroprotective Agents / isolation & purification
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Neuroprotective Agents / therapeutic use
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Pharmaceutical Preparations
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Plant Preparations / chemical synthesis
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Plant Preparations / chemistry
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Plant Preparations / isolation & purification
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Plant Preparations / therapeutic use
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Plants, Medicinal / chemistry*
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Structure-Activity Relationship
Substances
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Adjuvants, Immunologic
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Analgesics
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Anti-Inflammatory Agents
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Antimalarials
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Antineoplastic Agents, Phytogenic
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Antiviral Agents
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Cardiovascular Agents
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Hypoglycemic Agents
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Neuroprotective Agents
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Pharmaceutical Preparations
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Plant Preparations