Abstract
A surgical series of 59 patients with cerebellar or spinal cord hemangioblastomas or von Hippel-Lindau's (VHL) syndrome is analyzed. The presence of the tumor is easily detected by Computerized Tomography (CT) and Nuclear Magnetic Resonance (NMR), but angiography is still necessary for a correct surgical planning. The value of a sharp distinction among patients with single hemangioblastomas and the ones with Lindau's disease and VHL syndrome is stressed. In fact patients with single cerebellar or spinal hemangioblastomas have a good prognosis, while patients with disseminated hemangioblastomas have a rather poor outlook. Neuropathological studies with immunohistochemical techniques have been performed to identify the nature of the stromal cells of the hemangioblastomas: their origin from glial, endothelial and monociticphagocitic elements seems excluded.
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Cerebellar Neoplasms / pathology
-
Cerebellar Neoplasms / physiopathology*
-
Cerebellar Neoplasms / surgery*
-
Child
-
Diagnosis, Differential
-
Female
-
Follow-Up Studies
-
Glial Fibrillary Acidic Protein / analysis
-
Hemangiosarcoma / pathology
-
Hemangiosarcoma / physiopathology*
-
Hemangiosarcoma / surgery*
-
Humans
-
Immunohistochemistry
-
Magnetic Resonance Spectroscopy
-
Male
-
Middle Aged
-
Muramidase / analysis
-
Retrospective Studies
-
Spinal Cord Neoplasms / pathology
-
Spinal Cord Neoplasms / physiopathology*
-
Spinal Cord Neoplasms / surgery*
-
Vimentin / analysis
-
alpha 1-Antichymotrypsin / analysis
-
alpha 1-Antitrypsin / analysis
-
von Hippel-Lindau Disease / pathology
-
von Hippel-Lindau Disease / physiopathology
-
von Hippel-Lindau Disease / surgery*
-
von Willebrand Factor / analysis
Substances
-
Glial Fibrillary Acidic Protein
-
Vimentin
-
alpha 1-Antichymotrypsin
-
alpha 1-Antitrypsin
-
von Willebrand Factor
-
Muramidase