Abstract
We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Antigens, CD / biosynthesis
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Antigens, CD / blood
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Antigens, CD / immunology*
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Apoptosis Regulatory Proteins / biosynthesis
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Apoptosis Regulatory Proteins / blood
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Apoptosis Regulatory Proteins / immunology*
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Biomarkers
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CD28 Antigens / biosynthesis
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CD28 Antigens / blood
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CD28 Antigens / immunology
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CD4-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / immunology*
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Female
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Hepacivirus / immunology*
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Hepatitis C / blood
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Hepatitis C / immunology*
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Hepatitis C / physiopathology
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Hepatitis C, Chronic / blood
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Hepatitis C, Chronic / immunology
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Hepatitis C, Chronic / physiopathology
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Humans
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Immunity, Cellular
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Liver / immunology
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Male
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Middle Aged
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Predictive Value of Tests
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Prognosis
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Programmed Cell Death 1 Receptor
Substances
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Antigens, CD
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Apoptosis Regulatory Proteins
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Biomarkers
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CD28 Antigens
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PDCD1 protein, human
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Programmed Cell Death 1 Receptor