The emerging role of innate immunity in protection against HIV-1 infection

Vaccine. 2008 Jun 6;26(24):2997-3001. doi: 10.1016/j.vaccine.2007.11.060. Epub 2007 Dec 17.

Abstract

Preventive immunization against HIV-1 infection requires a rapid immune response that does not rely exclusively on B or T cell memory. Innate immunity may fulfill this function as it may be activated directly at the time of HIV-1 transmission, inhibit early HIV-1 replication, stimulate adaptive immunity and enable specific antibodies followed by CD8(+) T cells to deal with the virus effectively. The three components of innate immunity - cellular, extracellular and intracellular - are presented, with an example given for each of these components; gammadelta T cells, CC chemokines and APOBEC3G. This brief account is presented to highlight the immuno-virological concept of coordinating activated innate immunity with adaptive antibody and T cell responses in preventive vaccination against HIV-1 infection.

Publication types

  • Review

MeSH terms

  • APOBEC-3G Deaminase
  • Chemokines, CC / immunology
  • Cytidine Deaminase / immunology
  • HIV Infections / immunology*
  • HIV Infections / prevention & control
  • HIV-1 / immunology*
  • Humans
  • Immunity, Innate*
  • Interferon Type I / immunology
  • Receptors, Antigen, T-Cell, gamma-delta / immunology
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes / immunology
  • Vaccination

Substances

  • Chemokines, CC
  • Interferon Type I
  • Receptors, Antigen, T-Cell, gamma-delta
  • APOBEC-3G Deaminase
  • APOBEC3G protein, human
  • Cytidine Deaminase