Abstract
In a university hospital, time-series analysis revealed a significant relationship between antibiotic (aminoglycoside, fluoroquinolone, and cefepime) use and incidence of MexXY-OprM-overproducing Pseudomonas aeruginosa. In vitro experiments confirm that such mutants were readily selected from both PAO1 and clinical strains when grown in the presence of these antibiotics.
MeSH terms
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Aminoglycosides / pharmacology
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Aminoglycosides / therapeutic use
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / metabolism*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Cefepime
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Cephalosporins / pharmacology
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Cephalosporins / therapeutic use
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Culture Media
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Drug Resistance, Multiple / genetics*
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Fluoroquinolones / pharmacology
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Fluoroquinolones / therapeutic use
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France
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Hospitals, University
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Humans
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Incidence
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Membrane Transport Proteins / genetics
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Membrane Transport Proteins / metabolism*
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Microbial Sensitivity Tests
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Mutation
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Pseudomonas Infections / drug therapy*
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / isolation & purification
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Pseudomonas aeruginosa / metabolism
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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Cephalosporins
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Culture Media
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Fluoroquinolones
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Membrane Transport Proteins
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MexXY protein, Pseudomonas aeruginosa
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OprM protein, Pseudomonas aeruginosa
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Cefepime