Intestinal injury associated with spiramycin therapy of Cryptosporidium infection in AIDS

C Weikel; A Lazenby; P Belitsos; M McDewitt; H E Fleming Jr; M Barbacci

Intestinal injury associated with spiramycin therapy of Cryptosporidium infection in AIDS

J Protozool. 1991 Nov-Dec;38(6):147S.

Authors

C Weikel¹, A Lazenby, P Belitsos, M McDewitt, H E Fleming Jr, M Barbacci

Affiliation

¹ Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

PMID: 1818145

Abstract

Two of three patients treated with high doses of spiramycin for Cryptosporidium infection developed acute intestinal injury. Spiramycin at high doses may be directly toxic to the intestinal epithelium and thus may have limited utility as therapy for cryptosporidiosis in AIDS patients.

Publication types

Case Reports

MeSH terms

Acquired Immunodeficiency Syndrome / complications*
Adult
Coccidiostats / adverse effects*
Coccidiostats / therapeutic use
Cryptosporidiosis / complications
Cryptosporidiosis / drug therapy*
Dose-Response Relationship, Drug
HIV Seropositivity / complications
Humans
Intestines / drug effects*
Male
Spiramycin / adverse effects*
Spiramycin / therapeutic use

Substances

Coccidiostats
Spiramycin