Proteolytic activity of Cu(II) complex of 1-oxa-4,7,10-triazacyclododecane

Org Lett. 2008 Feb 7;10(3):481-4. doi: 10.1021/ol702860h. Epub 2008 Jan 9.

Abstract

Proteolytic activity of the Cu(II) complex of 1-oxa-4,7,10-triazacyclododecane (oxacyclen) was compared with that of the Cu(II) complex of 1,4,7,10-tetraazacyclododecane by using albumin, gamma-globulin, and myoglobin as substrates. Values of kcat/Km were greater for Cu(II)oxacyclen by 40-80 times. The enhanced activity is attributed to the increased Lewis acidity of Cu(II) due to substitution of one nitrogen donor atom with oxygen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Copper / chemistry*
  • Hydrolysis
  • Metalloproteases / chemical synthesis*
  • Metalloproteases / metabolism
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / metabolism

Substances

  • Organometallic Compounds
  • Copper
  • Metalloproteases