XMAP215: a tip tracker that really moves

Cell. 2008 Jan 11;132(1):19-20. doi: 10.1016/j.cell.2007.12.019.

Abstract

XMAP215 is a microtubule plus-end binding protein implicated in modulating microtubule dynamics. In this issue, Brouhard et al. (2008) propose a new mechanism to explain how XMAP215 promotes microtubule growth. They report that XMAP215 moves with the growing microtubule plus ends where it catalyzes the addition of tubulin subunits.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Biological Assay / methods
  • Cell Differentiation / physiology
  • Cell Enlargement
  • Green Fluorescent Proteins / analysis
  • Green Fluorescent Proteins / metabolism
  • Macromolecular Substances / metabolism
  • Microtubule-Associated Proteins / metabolism*
  • Microtubules / metabolism*
  • Microtubules / ultrastructure
  • Protein Binding / physiology
  • Protein Transport / physiology
  • Tubulin / metabolism*
  • Xenopus Proteins / metabolism*

Substances

  • CKAP5 protein, Xenopus
  • Macromolecular Substances
  • Microtubule-Associated Proteins
  • Tubulin
  • Xenopus Proteins
  • Green Fluorescent Proteins