Fluoxetine (Prozac) augments platelet activation mediated through protease-activated receptors

J Thromb Haemost. 2008 Apr;6(4):705-8. doi: 10.1111/j.1538-7836.2008.02896.x. Epub 2008 Jan 9.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adenine / analogs & derivatives
  • Adenine / pharmacology
  • Antigens, CD / blood
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism
  • Cytoplasmic Granules / drug effects
  • Cytoplasmic Granules / metabolism
  • Drug Synergism
  • Fluoxetine / pharmacology*
  • Humans
  • Methysergide / pharmacology
  • Oligopeptides / pharmacology
  • P-Selectin / blood
  • Peptide Fragments / pharmacology
  • Platelet Activation / drug effects*
  • Platelet Membrane Glycoproteins
  • Receptor, PAR-1 / agonists*
  • Receptor, Serotonin, 5-HT2A / drug effects
  • Receptors, Purinergic P2 / drug effects
  • Receptors, Purinergic P2Y1
  • Receptors, Purinergic P2Y12
  • Receptors, Thrombin / agonists*
  • Selective Serotonin Reuptake Inhibitors / pharmacology*
  • Serotonin / blood
  • Tetraspanin 30
  • Thrombin / agonists
  • Thrombin / pharmacology
  • Valerates / pharmacology

Substances

  • 2,2-dimethylpropionic acid 3-(2-chloro-6-methylaminopurin-9-yl)-2-(2,2-dimethylpropionyloxymethyl)propyl ester
  • Antigens, CD
  • CD63 protein, human
  • Oligopeptides
  • P-Selectin
  • P2RY1 protein, human
  • P2RY12 protein, human
  • Peptide Fragments
  • Platelet Membrane Glycoproteins
  • Receptor, PAR-1
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Purinergic P2
  • Receptors, Purinergic P2Y1
  • Receptors, Purinergic P2Y12
  • Receptors, Thrombin
  • Serotonin Uptake Inhibitors
  • Tetraspanin 30
  • Valerates
  • alanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanine
  • thrombin receptor peptide (42-47)
  • Fluoxetine
  • Serotonin
  • Thrombin
  • Adenine
  • protease-activated receptor 4
  • Methysergide