Abstract
While most Staphylococcus aureus telithromycin-resistant mutants isolated in this study possessed duplications within rplV (encoding ribosomal protein L22), four isolates possessed insertions within rplV that were identical to a portion of the gene rplB (encoding ribosomal protein L2). This novel type of mutation is the result of an apparent gene conversion-like event.
MeSH terms
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Amino Acid Sequence
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Anti-Bacterial Agents / pharmacology*
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Base Sequence
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Drug Resistance, Bacterial / genetics*
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Gene Conversion*
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Ketolides / pharmacology*
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation*
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Ribosomal Proteins / genetics*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / genetics
Substances
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Anti-Bacterial Agents
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Ketolides
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Ribosomal Proteins
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ribosomal protein L2
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telithromycin