Abstract
Microinjections of serotonin and glutamic acid into the globus pallidus in conditions of free selection between a light and a dark chamber showed these substances to have antiaversive activity in rats in the "threatening situation" test but not in the "illuminated area" test. Local administration of dopamine and GABA into this basal ganglia formation had no effect on the mechanisms of voluntary movement but countered anxiety states in both behavioral models. These results provide evidence that the neurotransmitter systems of the dorsal pallidum have different degrees of involvement in the operative control of behavior when the modality of the aversive stimulus changes.
MeSH terms
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Amino Acids / agonists
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Amino Acids / antagonists & inhibitors
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Amino Acids / pharmacology*
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Animals
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Anxiety / prevention & control*
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Anxiety / psychology*
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Biogenic Monoamines / agonists
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Biogenic Monoamines / antagonists & inhibitors
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Biogenic Monoamines / pharmacology*
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Conditioning, Operant / drug effects
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Globus Pallidus / drug effects
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Globus Pallidus / physiology*
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Glutamic Acid / administration & dosage
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Glutamic Acid / pharmacology
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Male
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Microinjections
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Motivation
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Motor Activity / drug effects
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Rats
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Reinforcement, Psychology
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Serotonin / pharmacology
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gamma-Aminobutyric Acid / administration & dosage
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gamma-Aminobutyric Acid / pharmacology
Substances
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Amino Acids
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Biogenic Monoamines
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Serotonin
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Glutamic Acid
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gamma-Aminobutyric Acid