1 Duke Human Vaccine Institute, Departments of Medicine, Pathology, and Immunology, Duke University School of Medicine, Durham, NC 27710, USA. [email protected] <[email protected]>
In this issue, Sun et al. (2008) model the interface between a neutralizing antibody and HIV-1 glycoprotein 41 (gp41) envelope peptide in lipids. This model could help overcome a roadblock in HIV-1 vaccine development.