Abstract
Cutaneous Epstein-Barr virus (EBV)-associated B-cell lymphoma (EBVBL) in non-immunocompromised patients is very rare. Here, we report a case of cutaneous EBVBL in a 72-year-old Japanese woman without any signs of immunosuppression. She showed repeated high fever and skin eruptions on the face, limbs and palms. Histological diagnosis was diffuse large B-cell lymphoma. EBV infection was detected by in situ hybridization and Southern blotting. Immunostaining for viral proteins showed the patient to be positive for latent membrane protein 1 (LMP-1) and negative for Epstein-Barr virus nuclear antigen-1 (EBNA-2), indicating that a type II latency EBV infection pattern.
MeSH terms
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Aged
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Aged, 80 and over
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Antigens, CD / analysis
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DNA, Viral / analysis
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Epstein-Barr Virus Infections / complications
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Epstein-Barr Virus Infections / immunology*
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Fatal Outcome
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Female
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Herpesvirus 4, Human / genetics
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Herpesvirus 4, Human / isolation & purification*
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Humans
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Immunocompetence
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Immunologic Techniques
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Lymphoma, Large B-Cell, Diffuse / immunology
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Lymphoma, Large B-Cell, Diffuse / pathology
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Lymphoma, Large B-Cell, Diffuse / virology*
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Male
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Middle Aged
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RNA, Viral / analysis
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Skin Neoplasms / immunology
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Skin Neoplasms / pathology
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Skin Neoplasms / virology*
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Viral Matrix Proteins / analysis
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Virus Latency
Substances
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Antigens, CD
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DNA, Viral
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EBV-associated membrane antigen, Epstein-Barr virus
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RNA, Viral
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Viral Matrix Proteins