Abstract
Drugs antagonizing tumor necrosis factor (TNF) alpha have been increasingly and successfully used in the treatment of psoriasis vulgaris and psoriatic arthritis. We report a patient with TNF receptor 1-associated periodic syndrome (TRAPS) who received TNF-alpha antagonist etanercept. A month later, the patient developed for the first time generalized psoriasis vulgaris. This paradoxical phenomenon has been reported sporadically in patients receiving TNF-alpha antagonists for other inflammatory diseases. The cause of psoriasis induced by TNF-alpha antagonists is still obscure.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Biopsy
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Chromosomes, Human, Pair 12*
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Diagnosis, Differential
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Drug Eruptions / diagnosis*
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Drug Eruptions / genetics
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Drug Eruptions / pathology
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Etanercept
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Familial Mediterranean Fever / drug therapy*
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Familial Mediterranean Fever / genetics
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Familial Mediterranean Fever / pathology
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Humans
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Immunoglobulin G / adverse effects*
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Immunoglobulin G / therapeutic use
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Immunosuppressive Agents / adverse effects*
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Immunosuppressive Agents / therapeutic use
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Male
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Psoriasis / chemically induced*
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Psoriasis / diagnosis
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Psoriasis / genetics
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Psoriasis / pathology
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Receptors, Tumor Necrosis Factor / therapeutic use
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Receptors, Tumor Necrosis Factor, Type I / antagonists & inhibitors*
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Skin / pathology
Substances
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Immunoglobulin G
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Immunosuppressive Agents
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Receptors, Tumor Necrosis Factor
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Receptors, Tumor Necrosis Factor, Type I
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Etanercept